Printer-friendly versionProteomics Data Management: Instrument and Robotics Integration and Automation
The Proteus solution supports bioinformatics pipelining of proteomics data. Proteus supports an unparalleled variety of instruments with multiple levels of integration including in-depth integrations for leading-edge gel and mass spectrometry platforms. All instrument software types are supported when simply storing data with notes and procedural parameters is all that is required.
Gel images are collected in conjunction with spot picking and gel analysis software to provide end-to-end linkages of the protein information to the gel spots. All the common gel based equipment is supported out-of-the-box, including imagers, spot pickers and robotic handlers. Workflows for multiplexed gels, such as DiGE experiments, are also supported.
Mass spectrometry equipment is also tightly integrated. Spectra data is collected and viewed in context with the experiment and sample tracking. Raw spectra and peak lists can be automatically collected from the instrument. The automated capture ensures that the sample, procedural and results data are collected easily, accurately and securely.
Proteomics Data Management: Analytical Software Integration and Automation
Proteus is built to support superior analytics, whether you use specialized in-house or best-in-class commercial tools. Protein search results are imported into Proteus and available for review and comparison. Both peptide and protein views are available and searchable. You can tailor the fields to track in your analysis and import the data using a simple comma separated file. Further details, such as sequence information, can be linked from public Web-based repositories.
Proteus supports major search engines, including:
• Mascot
• ABI Protein Pilot
• Sequest Bioworks
• Phenyx
• Spectrum Mill
• X!Tandem
Proteomics Data Management: Quantitation Results
Quantitation results are also available for review. For example, PeptideProphet and ProteinProphet quantitation results from the Institute for Systems Biology are integrated through the open protXML and pepXML formats.
Proteomics Data Management: Protein and Peptide Comparison Views
Comparing multiple analytical results is available across samples, experiments and projects. In addition to the protein and peptide comparison views, additional analysis is available in Proteome Software’s Scaffold analysis. The search results are automatically sent to Scaffold for statistical validation. The validated results are available in Proteus for review and dissemination to researchers and collaborators.
As proteomics analytical tools evolve, GenoLogics continues to integrate with them through partnerships and collaborations with vendors. Bioinformaticians may be interested in integrating their own programs and instrumentation by utilizing our Automated Informatics Framework.
Proteus is part of the GenoLogics suite of research informatics products for life sciences labs. The solution is built on our highly configurable research informatics platform, OMIX, which can be deployed across multiple sciences and facilities.
